Adding a certain compound to certain chemical reactions, such as: 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19094-56-5, Quality Control of 2-Chloro-5-iodobenzoic acid
Preparation 2-Chloro-5-iodo-N-(tricyclo[3.3.1.13’7]dec- 1 -ylmethyD-benzamide (Compound A); 5-Iodo-2-chlorobenzoic acid (40.0Og, 141.6mmol) was charged to a 500ml reaction vessel, followed by Bu4NCl (0.4Og, O.Oleq, 1.42mmol) and toluene (80ml, 2vol) under an inert atmosphere (N2). The suspension was heated to 70-75C, then thionyl chloride (12.40ml, 1.2eq, 169.94mmol) was added drop-wise over 30-60min. The resulting suspension is heated at 70-750C for approximately 3 hours. The reaction was monitored by HPLC (MeOH quench of sample) and on completion the reaction mixture, now a clear solution of 5-iodo-2-chlorobenzoyl chloride, was cooled to 20-250C
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2008/30160; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com