1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine
The steviol (30mg, 0.1mmol), K2CO3 (27mg, 0.2mmo 1) added to the dry flask, replace the nitrogen, then added 2mL anhydrous N, N-dimethylformamide (DMF), 3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine (1-1) (33mg0.13mmol) dissolved in 1mL N, N-dimethyl formamide, then added to the reaction under ice bath, and the mixture was heated to 70 C, and reacted for 6 hr. The mixture was subjected to thin layer chromatography (TLC), washed with 10% HCl, after washing with saturated brine and it was dried over anhydrous sodium sulfate and separation by column chromatography gave molecular probe 1 (white solid, 34 mg, 92% yield).
The synthetic route of 1450754-38-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Life Sciences Institute; Xiao Youli; Li Weichao; Zhou Yiqing; (27 pag.)CN108341781; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com