Related Products of 618-91-7,Some common heterocyclic compound, 618-91-7, name is Methyl 3-iodobenzoate, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: O-Tolualdehyde (0.24 mmol), iodobenzene (0.2 mmol), silver trifluoroacetate (0.3 mmol, 66 mg), palladium trifluoroacetate (0.02 mmol, 7 mg), Phe-Me2AA ligand (0.08 mmol, 19 mg), acetic acid (1.8 mL) and H2O (0.2 mL) were added to a vial. The mixture was heated to 90 C for 12 h. The reaction mixture was allowed to cool to room temperature and filtered through a silica gel pad, concentrated in vacuum. The desired product was isolated by a silica gel column chromatography or preparative TLC.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-iodobenzoate, its application will become more common.
Reference:
Article; Park, Hyojin; Yoo, Kwangho; Jung, Byunghyuck; Kim, Min; Tetrahedron; vol. 74; 16; (2018); p. 2048 – 2055;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com