Electric Literature of 13421-00-6,Some common heterocyclic compound, 13421-00-6, name is 5-Chloro-2-iodobenzoic acid, molecular formula is C7H4ClIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a argon gas puged mixture of 2-iodo benzoic acids (1) (0.008 mol), Carbonyldiimidazole(0.008 mol) and K2CO3 (0.242 mol) in CH3CN (50 ml) was added Pd(OAc)2 (10 mol %) andstirred at 60 oC temperature for 12h. The reaction was monitored by TLC analysis. Aftercompletion of the reaction, the reaction mixture was poured carefully into ice-cold water (50mL) and the product was extracted with ethyl acetate (2 x 50 mL). The combined organic layerwas dried over anhydrous Na2SO4. After filtration, the solvent was evaporated under vacuum andthe crude product obtained was purified by column chromatography to afford the pure desiredproducts (2a-d).
The synthetic route of 13421-00-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Narsimha, Sirassu; Battula, Kumaraswamy; Vasudeva Reddy, Nagavelli; Synthetic Communications; vol. 47; 9; (2017); p. 928 – 933;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com