Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-(3-Iodophenyl)acetic acid
Add 1,1-carbonyldimidazole (0.72 g, 4.40 mmol) to a solution of 3-iodo-phenylacetic acid (1.20 g, 4.6 mmol) in 40 mL of N,N-dimethylacetamide, followed by N,N-diisopropylethylamine (0.79 mL, 4.40 mmol). Stir the mixture at room temperature for 2 h, add 4-cyano-benzoic acid hydrazide (0.64 g (4.0 mmol) and heat the mixture to 60 C for 2 h. Cool the mixture to room temperature and dilute with H20 causing a solid to precipitate from solution. Collect the precipitate by filtration, wash with H20 and diethyl ether dry. Collect any further material that may crystallize from the filtrate. Extract the filtrate with CH2C12 and concentrate the combined organic phase provide a clear liquid. Dilute this mixture with H20 resulting in a third crop of material to precipitate from solution. Collect and combine all solid material to give 1.31 g, 71% yield of 4-cyano-benzoic acid iV-[2-(3-iodo-phenyl)-acetyl]-hydrazide as a powder.
According to the analysis of related databases, 1878-69-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KIRRANE, JR., Thomas Martin; MARSHALL, Daniel Richard; SIBLEY, Robert; SNOW, Roger John; SOLEYMANZADEH, Fariba; SORCEK, Ronald John; WO2012/54367; (2012); A1;,
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