Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, A new synthetic method of this compound is introduced below., name: 1,2-Difluoro-4-iodobenzene
In a glassware flask equipped with a condenser and a magnetic stirrer, were put 85.7 g (357 mmol) of 3,4-difluoroiodobenzene, 43.2 g (680 mmol) of copper powder, and 86 g of N-methylpyrrolidinone (NMP). The mixture was stirred under nitrogen atmosphere on an oil bath at 190 C for 5 h. After cooling to room temperature, the reaction mixture was mixed with 300 mL of tert-butyl methyl ether and filtered in order to remove copper and its salt. The filtrate was washed with water (300 mL x 3) and then with saturated aqueous sodium chloride solution (300 mL x 1), and dried with magnesium sulfate and filtered. The filtrate was evaporated and the resulting residue was column-chromatographed using hexane as an eluent to give a white solid (35 g, 87% yield) of product 4. The spectral data agreed with those of the authentic sample: 19F NMR (CDCl3) (with 1H decoupling) delta -136.88 (d, J = 21 Hz, 2F), -139.64 ppm (d, J = 21 Hz, 2F); 1H NMR (CDCl3) delta 7.25 (m, 4H), 7.34 ppm (m, 2H).
The synthetic route of 64248-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Umemoto; Zhou, Xiaocong; Li, Yuanqiang; Journal of Fluorine Chemistry; vol. 226; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com