Related Products of 216393-67-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 216393-67-8 name is 4-Chloro-2-fluoro-6-iodoaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2: synthesis of 4-chloro-2-fluoro-6-iodo-N- [2- (methylsulfonyl)ethyl] aniline A mixture of 4-chloro-2-fluoro-6-iodoaniline (0.5 g, 1.8 mmol), vinylmethylsulfone (0.2 g, 1.8mmol), Cs2CO3 (1.17 g, 3.6 mmol) and DMF (15 mL) was heated with stirring at 50Covernight. The resulting mixture was poured into water and then extracted with EA (50 mL x 3). The combined organic phases were dried over Na2504 and then concentrated. The residue was purified by column chromatography (EtOAc : PE = 1: 40) to give 4-chloro-2-fluoro-6-iodo-N- [2- (methylsulfonyl)ethyl] aniline (0.42 g, yield: 61%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-2-fluoro-6-iodoaniline, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; GAO, Lu; HONG, Di; WANG, Lisha; YUN, Hongying; ZHAO, Shu-Hai; WO2014/9302; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com