Electric Literature of 167479-01-8,Some common heterocyclic compound, 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, molecular formula is C8H16INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To the solution of 5-methoxy-1H-benzo[djimidazole-2-thiol (1.06 g, 5.9 mmol)in DMF (8 ml) at 0 C was added sodium bicarbonate (0.49 g, 5.9 mmol), and a solution of tert-butyl (3-iodopropyl)-carbamate (1.7 g, 5.9 mmol) in DMF (6 mL) dropwise. The resulting solution was stirred at 0 C overnight. The mixture was partitioned bewteen EtOAc and saturated NaHCO3. The organic phase was washed with saturated NaHCO3 three times, dried over Na2SO4, concentrated and the residue was purified on silica gel columnusing EtOAc/hexane as eluting solvents to give tert-butyl (3-((5-methoxy-1H- benzo[dj imidazol-2-yl)thio)propyl)carbamate. LC /MS: (M+ 1 ): 338.6
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (3-iodopropyl)carbamate, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Weiguo; DING, Fa-Xiang; SUN, Wanying; DEJESUS, Reynalda, Keh; TANG, Haifeng; HUANG, Xianhai; JIAN, Jinlong; GUO, Yan; WANG, Hongwu; (181 pag.)WO2017/155765; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com