Related Products of 75581-11-2, The chemical industry reduces the impact on the environment during synthesis 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, I believe this compound will play a more active role in future production and life.
Step 1 : Preparation of ethyl 2,2-difluoro-2-(4-methoxy-3-methylphenyl)acetateTo a solution 4-iodo-1 -methoxy-2-methylbenzene (commercially available, 1 equiv) and ethyl 2-bromo-2,2-difluoroacetate (2 equiv) in DMF (0.3M) was added Cu powder (3 equiv). The reaction slurry was heated to 80C for 1 .5 days, quenched with saturated NaH2P04 (aq) and extracted with ethyl acetate. The organics were dried over Na2S04 and concentrated under vacuum. The residual was purified via silica gel column chromatography to afford the title product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methoxy-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; CORTEZ, Alex; HOFFMAN, Timothy; LI, Yongkai; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue; WO2015/168279; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com