Synthetic Route of 443-85-6, These common heterocyclic compound, 443-85-6, name is 1-Fluoro-3-iodo-2-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-Bromosuccinimide (NBS, 3.77 g, 21.2 mmol) and benzoyl peroxide (77 mg,0.32 mmol) were added to a solution of 1-fluoro-3-iodo-2-methylbenzene10b (5.0 g, 21.2 mmol) in CCl4 (55 mL). The mixture was heated to reflux for 48 hours then cooled to roomtemperature. The suspension was filtered and the filtrate concentrated underreduced pressure to yield an orange oil. Purification over silica eluting withpentane provided the title compound as a white solid (3.8 g, 67% yield). 1HNMR (400MHz, CDCl3): d 7.65 (d, 1H), 7.09-6.98(m, 2H), 4.65 (s, 2H); Also a knowncommercially available compound.
Statistics shows that 1-Fluoro-3-iodo-2-methylbenzene is playing an increasingly important role. we look forward to future research findings about 443-85-6.
Reference:
Article; Roberts, Lee R.; Corbett, Matthew S.; Fussell, Steven J.; Hitzel, Laure; Jessiman, Alan S.; Mason, Helen J.; Osborne, Rachel; Ralph, Michael J.; Stennett, Adam S.D.; Wheeler, Simon; Storer, R. Ian; Tetrahedron Letters; vol. 56; 47; (2015); p. 6546 – 6550;,
Iodide – Wikipedia,
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