Application of 628-77-3, A common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, molecular formula is C5H10I2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A dry argon-flushed flask was charged with 2 (302 mg,1 mmol) and anhydrous THF (18 ml). The solution wascooled to 0 C and n-BuLi (1.18 ml, 2 mmol, 1.7 M solutionin THF) was added dropwise over 10 min and the reactionmixture was stirred for 1 h. In a second flask 1,5-diiodopentaneor 1,10-diiododecane (6 mmol) was dissolved in 3 mlof dry THF and added to the solution of lithiated speciesvia a cannula. The reaction mixture was allowed to reachroom temperature and was stirred for 3 h before quenchedwith a saturated solution of NH4Cl(30 ml). The aqueouslayer was extracted with hexane (3 × 25 ml). The combinedorganic layers were washed with brine (1 × 50 ml), water(1 × 50 ml), dried over MgSO4and filtered. Solvents wereevaporated under reduced pressure and the crude reactionmixture was purified by column chromatography on silicagel using hexane:EtOAc as the mobile phase with a gradientelution mixture (20:1, 10:1, 5:1).
The synthetic route of 628-77-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Luka?ek, Jan; ?ezankova, Marketa; Stibor, Ivan; ?ezanka, Michal; Journal of Inclusion Phenomena and Macrocyclic Chemistry; vol. 92; 3-4; (2018); p. 339 – 346;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com