Synthetic Route of 19094-56-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: The mixture of 5-bromo-2-chloro-4-(piperazin-1-yl)pyrimidinedihydrochloride 4 (0.00285 mol), substituted acid (0.00371 mol)and N, N, dimethylformamide (10 V) was cooled to 0e5 C. Further,N, N-Diisopropylethylamine (0.0142 mol), HATU (0.00371 mol) wasadded slowly at 0e5 C and mixture was stirred for 20 min. Thereaction mass warmed to 25e30 C and stirred for 16 h. Aftercompletion of reaction, the reaction mass was diluted with ethylacetate (25 V), organic layer was washed using 1 M citric acid solution,1 M lithium hydroxide solution and followed by water.Organic layer was concentrated and triturated using n-heptane.Reaction mass was filtered off and obtained solid was recrystallizedwith suitable solvent to obtain titled compounds.
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-5-iodobenzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Article; Munikrishnappa, Chandrashekar Suradhenupura; Puranik, Sangamesh B.; Kumar, G.V. Suresh; Prasad, Y. Rajendra; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 70 – 82;,
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