Reference of 450412-28-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450412-28-9, name is 1-Bromo-3-chloro-2-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1-bromo-3-chloro-2-iodobenzene 200.00 g (1.0 eq),2-aminophenol 68.77 g (1.0 eq), K3PO4 267.55 g (2.0 eq),1.61 g (0.005 eq) of Pd (t-Bu3P) 2 was dissolved in 1.5 L of toluene, refluxed and stirred.The solution was concentrated under reduced pressure for 3 hours.After that, it was completely dissolved in CHCl3, washed with water and decompressed again to remove about 50% of the solvent. Ethyl acetate was added in the refluxing state, and the crystals were dropped, cooled, and filtered. This was subjected to column chromatography to obtain 137.35 g (yield 73%) of a compound represented by the formula 7-a.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-chloro-2-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LG Chem, Ltd.; Kim Min-jun; Park Tae-yun; Cho Seong-mi; Lee Jeong-ha; (88 pag.)KR2017/113319; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com