Synthetic Route of 4897-68-1,Some common heterocyclic compound, 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, molecular formula is C7H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 135mg (1mmol) benzothiazole, 376mg (1.2mmol) 1- bromo-2-iodo-4-methoxybenzene, 2.5mg (0.01mmol) CuSO4ยท5H2O, 19.4mg (0.1mmol) ligand L4,240mg (6mmol) NaOH, 2gPEG-600, was added 10mL reaction tube, sealed, under the reaction condition of 80 14h.After the reaction was stopped, extraction with ethyl acetate, washed with water, brine, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated under reduced pressure, purified by silica gel column chromatography separation and purification, to give 3-methoxy-phenothiazine 172mg, yield 75%.
The synthetic route of 4897-68-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sun Yat-sen University; Wan, Yiqian; Huang, Manna; Huang, Dongting; Zhu, Xinhai; (11 pag.)CN104529938; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com