Adding a certain compound to certain chemical reactions, such as: 56404-21-8, name is 1-Iodo-2,4-dimethyl-3-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56404-21-8, Application In Synthesis of 1-Iodo-2,4-dimethyl-3-nitrobenzene
A three-necked flask equipped with a thermometer, a gas inlet, and a magnetic stirring bar was charged under argon with MnBr2 (320mg, 1.5mmol) in DMPU (25ml). CuCl (85mg, lmmol), ethyl 4-bromobutyrate (5.85g, 30mmol) and Et2Zn (2.7ml, 27mmol) were successively added. The reaction mixture turned dark red and was stirred for 4 h at 25 0C. After cooling to -30 0C, a solution of Cl2Pd(dppf) (0.925g, lOmmol) and 2,4-dimethyl-3-nitroiodobenzene (6.93g, 25mmol) in anhydrous THF (25ml) was slowly added. The reaction mixture was warmed to 25 C for 30 min and was then stirred at 65 C overnight and quenched with an aqueous 2N HCl solution (100ml). This mixture was extracted with CH2Cl2 three times, and the organic layer was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure, and the crude residue obtained was purified by Biotage (hexane/EtOAc, 0-30%, 40min) to give 4.5g of yellow oily products (68 %). 1H-NMR delta (CDCl3, 300MHz): 7.13 (d, J=7.8Hz, IH), 7.03 (d, J=7.8Hz, IH), 4.12 (q, J=7.2Hz, 2H), 2.64 (t, J=7.8Hz, 2H), 2.34 (t, J=7.8Hz, 2H), 2.23 (s, 3H), 2.20 (s, 3H), 1.86 (m, J=7.8Hz, 2H), 1.24 (t, J=7.8Hz, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-2,4-dimethyl-3-nitrobenzene, and friends who are interested can also refer to it.
Reference:
Patent; VALEANT PHARMACEUTICALS INTERNATIONAL; WO2008/66900; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com