Synthetic Route of 401-81-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A mixture of the aryl halide (1 mmol), NH4OH (2 mmol), Cs2CO3 (1 mmol) and P4PVy-CuI (0.1 g) in CH3CN (10 mL) was stirred at reflux temperature. After reaction completion (moitored by TLC), the catalyst was recovered by filtration and solvent was evaporated. The residue was poured into a saturated NaCl solution, extracted with ethyl acetate and dried over anhydrous MgSO4. Evaporation of the solvent was followed by column chromatography on silica gel afforded the pure products.
The chemical industry reduces the impact on the environment during synthesis 1-Iodo-3-(trifluoromethyl)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Article; Albadi, Jalal; Shiran, Jafar Abbasi; Mansournezhad, Azam; Acta Chimica Slovenica; vol. 61; 4; (2014); p. 900 – 903;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com