Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74534-15-9, name is 1-Chloro-2-iodo-4-nitrobenzene, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
Iron (5 eq, 1.9 g) was added to a solution of 1-chloro-2-iodo-4-nitro-benzene (1eq, 1.95 g) in acetic acid (28 mL, 0.25M). The reaction was stirred at70C for 1 h then cooled to room temperature and filtered through celite. The crudereaction mixture was extracted with a solution of saturated ammonium chloride andethyl acetate, dried with magnesium sulfate, filtered and concentrated under vacuum toafford crude 4-chloro-3-iodo-aniline as a red oil, which was used in the next step withoutpurification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Khojasteh, S. Cyrus; Yue, Qin; Ma, Shuguang; Castanedo, Georgette; Chen, Jacob Z.; Lyssikatos, Joseph; Mulder, Teresa; Takahashi, Ryan; Ly, Justin; Messick, Kirsten; Jia, Wei; Liu, Lichuan; Hop, Cornelis E. C. A.; Wong, Harvey; Drug Metabolism and Disposition; vol. 42; 3; (2014); p. 343 – 351;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com