Related Products of 199850-56-1, The chemical industry reduces the impact on the environment during synthesis 199850-56-1, name is Methyl 2-amino-4-chloro-5-iodobenzoate, I believe this compound will play a more active role in future production and life.
Intermediate 11 1 : 7-Chloro-4-hvdroxy-6-iodo-3-(o-tolyloxy)quinolin-2(1 H)-oneMethyl 2-amino-4-chloro-5-iodobenzoate (Intermediate 2) (1 g, 3.21 mmol) and ethyl 2-(o- tolyloxy)acetate (Aldrich, 0.655 g, 3.37 mmol) were dissolved in THF (10 mL) and KHMDS 1 M/THF (9.63 mL, 9.63 mmol) was added in one portion at room temperature under N2. The reaction mixture was stirred at room temperature for 1 h before quenched with MeOH and concentrated under reduced pressure. The residue was dissolved in 1 N NaOH then extracted with Et20. The aqueous extracts were acidified with 1 N HCI and the resulting precipitate was collected by filtration then washed successively with water and diethyl ether to give 7-chloro-4-hydroxy-6-iodo-3-(o-tolyloxy)quinolin-2(1 H)-one (1.03 g, 2.409 mmol, 75 % yield) as white solid. LCMS: (M+H)+ = 428; Rt = 2.46 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-chloro-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; DAUGAN, Alain Claude-Marie; LAMOTTE, Yann; MIRGUET, Olivier; WO2012/119978; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com