Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H4F3I
To a solution of 7-ethynyl-2,2-dimethyl-2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-one 29 (0.25 g, 1.23 mmol) in DMSO (3.0 mL) was added copper(I) iodide (0.005 g, 0.026 mmol), dichlorobis(triphenyl- phosphine)palladium (II) (0.034 g, 0.37 mmol), triethylamine (1.0 mL), 1-iodo-2-(trifluoromethyl)- benzene (0.505 g, 1.85 mmol). The reaction mixture was further stirred at 100 °C for 4 h. After the completion of reaction, the reaction mixture was filtered through celite bed. The filtrate was quenched with water, extracted with ethyl acetate and concentrated. The crude compound was purified by flash chromatography using 10-20percent ethyl acetate in hexane to provide title compound 30a (0.2 g) in 46percent yield. 1H NMR (CDCl3): delta 1.54 (s, 6H), 2.80 (s, 2H), 7.27 (s, 1H), 7.48 (d, J = 7.80 Hz, 1H), 7.58 (d, J = 6.9 Hz, 1H), 7.73 (t, J = 7.8 Hz, 2H), 8.20 (d, J = 7.8 Hz, 1H); MS [M+H]+: 346.14.
The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Muthukaman, Nagarajan; Tambe, Macchindra; Shaikh, Mahamadhanif; Pisal, Dnyandeo; Deshmukh, Sanjay; Tondlekar, Shital; Sarode, Neelam; Narayana, Lakshminarayana; Gajera, Jitendra M.; Kattige, Vidya G.; Honnegowda, Srinivasa; Karande, Vikas; Kulkarni, Abhay; Behera, Dayanidhi; Jadhav, Satyawan B.; Gudi, Girish S.; Khairatkar-Joshi, Neelima; Gharat, Laxmikant A.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 11; (2017); p. 2594 – 2601;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com