Synthetic Route of 2142-70-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2142-70-3 as follows.
A solution of 1-(2-iodophenyl)ethanone (0.86g, 3.49mmol) in THF (l5mL) was treated with trimethylphenylammonium tribromide (1.31g, 3.49mmol) in small portions over 10 minutes at R.T. The resulting yellow suspension was stirred at R.T. for 2 hours. A whiteprecipitate formed and was filtered, washed with diethyl ether and the filtrate was concentrated under reduced pressure to give the crude product. The product was purified by silica column chromatography using Combiflash RF automated purification system (0-100% EtOAc – hexane gradient elution) to give title compound as a yellow oil. The oil was confirmed as desired product by 1H NMR (500MHz ODd3) O 7.97(1 H, d, J=11Hz, ArH), 7.47(2 H, d, J= 8Hz, ArH), 7.18-7.22(1 H, m, J= 4, 12Hz, ArH), 4.47(2 H, 5, CH2Br).
According to the analysis of related databases, 2142-70-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF DUNDEE; SMITH, Alasdair; HUGGETT, Margaret Jean; SPINKS, Daniel; WOODLAND, Andrew; GILBERT, Ian Hugh; (156 pag.)WO2016/132134; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com