Adding a certain compound to certain chemical reactions, such as: 116632-39-4, name is 5-Bromo-2-iodotoluene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 116632-39-4, Recommanded Product: 116632-39-4
Compound Kl 09 can be synthesized by a person of ordinary skill following Scheme 2 illustrated in FIG. 3. In the first step, compound S2-1 (available for purchase from Acros Organics, CAS No. 86-74-8) is combined with compound S2-2 (available for purchase from Alfa Aesar, CAS No. 116632-39-4), K2C03, and Cul in toluene at 80 C to form compound S2-3, In the second step, compound S2-3 is added to hexanes and cooled to 0 C before dropwise addition of nBuLi, followed by addition of B(OMe)3. The reaction can be allowed to stir before being quenched with aqueous HCl to form compound S2-4. In the third step, compound S2-4 is combined with compound S2-5 (available for purchase from Alfa Aesar, CAS No. 3842-55-5), Pd(OAc)2 and K3P04 in THF at 45 C for 24 hours to form compound Kl 09. It is understood that steps 1 , 2, and 3 can be performed and optimized by a person having ordinary skill in the art without undue experimentation.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-2-iodotoluene, and friends who are interested can also refer to it.
Reference:
Patent; Harvard College Dean Deng; A ·asipulu-gujike; R ·gemaisi-bomubaleierli; T ·D·xiseer; J ·akuileila-aipalakuilei; R ·P·yadangsi; D ·maikelaolin; D ·K·duweinade; (333 pag.)CN106661001; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com