Application of 628-77-3,Some common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, molecular formula is C5H10I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 141:(S)-1 -(1 -(4-bromophenyl)ethyl)piperidineTo a solution of (S)-i -(4-bromophenyl)ethanamine (1 .439 mL, 10.00 mmol) in DMF, were added potassium carbonate (4.14 g, 30.0 mmol) and 1,5-di- iodopentane (2.98 mL, 19.99 mmol). The reaction mixture was heated at 90 C in DMF for 16 h. The reaction mixture was concentrated, the product was extractedwith ethyl acetate and purification was done using column chromatography (silica gel, 30 % CHCI3 in DCM) to yield the title compound.Yield: 2 g (74.6%); 1H NMR (DMSO-d6, 300 MHz): 6 7.4 – 7.6 (d, 2H), 7.1 – 7.3 (d, 2H), 3.2 – 3.3 (m, 1 H), 2.1 – 2.4 (m, 4H), 1.4 – 1.5 (m, 4H), 1.3 – 1.4 (m,2H), 1.1 – 1.2 (m, 3H); MS (ESl+): m/z 269 [M+H] HPLC Purity: 96.30 %.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Diiodopentane, its application will become more common.
Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; ROYCHOWDHURY, Abhijit; SHARMA, Rajiv; GUPTE, Amol; KANDRE, Shivaji; GADEKAR, Pradip, Keshavrao; CHAVAN, Sambhaji; JADHAV, Ravindra, Dnyandev; THAKRE, Gajanan, Amrutrao; BAJAJ, Komal; JANRAO, Ravindra, Ashok; DEHADE, Amol; GAIKWAD, Nitin; KADAM, Kishorkumar; MORE, Tulsidas, Sitaram; GUHA, Tandra; SEELABOYINA, Balapadmasree; SABLE, Vikas, Vasant; WO2015/110999; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com