Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14452-30-3, name is 1-(3-Iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 14452-30-3
General procedure: All the chemicals and solvents were purchased from Sigma Aldrich. The progress of all reactions was monitored on Merck KGaA precoated silica gel plates 0.25 mm (with fluorescence indicator UV254) using ethyl acetate/n-hexane as solvent system. Spots were visualized by irradiation with ultraviolet light (254 nm). Melting points (mp) were determined using open capillary method on Melting Point III Marte apparatus. Proton (1H) and (13C) NMR spectra were recorded on Bruker Avance 400 spectrometer at 400 MHz for 1H and 100 MHz for 13C using DMSO-d6 and CDCl3 as solvents referenced. Chemical shifts are given in parts per million (ppm) (delta relative to residual solvent peak for 1H and 13C). Spectra Mass was performed on a LCMS-2020 Liquid Chromatograph Mass Spectrometer Shimadzu, the column was Agilent XDB-C18, 35 muM, 21×20 nm. IR spectra were recorded on a PerkinElmer model Spectrum 400 (medium, sweep of 4000 to 400 cm-1). Synthesized compounds were ?96% pure as determined by high performance liquid chromatography (HPLC) Shimadzu with PDA detector, Nucleodur 100-5 CN-RP column 205×4.6mm, mobile phase water/0.1% TFA and acetonitrile with flow of 1mL/min. For the synthesis of 3-25, substituted acetophenones (0.5 equiv, 0.5 mmol) and nitroaromatics (0.5 equiv. 0.5 mmol) were dissolved in acetic acid (1mL) and concentrated sulfuric acid (0.05 mL) and were stirred at 100C until completion of the reaction (4-24h). The cooled mixture and the solid was washed with iced methanol (200 mL) for purification. For the synthesis of 26-35, 0.4 mL of aqueous NaOH (20% w/v) was added to the solution of the acetophenones substituted in 4? position (1 mmol) in EtOH. The resulting mixture was stirred at the room temperature for 10 h. The formed precipitate was filtered and washed with cold water. If no precipitation occurred, the resulting mixture was neutralized with 5% HCl filtered and dried. The crude was then subjected to chromatography column with EtOAc/Hexane (7:3, v/v) as eluent.
According to the analysis of related databases, 14452-30-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Gomes, Marcelo N.; Braga, Rodolpho C.; Grzelak, Edyta M.; Neves, Bruno J.; Muratov, Eugene; Ma, Rui; Klein, Larry L.; Cho, Sanghyun; Oliveira, Guilherme R.; Franzblau, Scott G.; Andrade, Carolina Horta; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 126 – 138;,
Iodide – Wikipedia,
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