In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 618-91-7, name is Methyl 3-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 618-91-7
General procedure: To a solution of 3 (117mg, 1.0mmol), methyl 4-iodobenzoate (288mg, 1.1mmol), Pd(PPh3)2Cl2 (21mg, 0.03mmol), and CuI (5mg, 0.03mmol) in the mixture of THF (20mL) and triethylamine (20mL) was added under a nitrogen atmosphere. After being stirred at 70C for 6h, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography with dichloromethane/petroleum ether (1:2, v/v) as the eluent to afford the pure product 5a (221mg, 0.88mmol) as a light brown powder in 88% yield.
The synthetic route of 618-91-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Zhiqiang; Ge, Haojie; Han, Xie; Liu, Sheng Hua; Meng, Xiang-Gao; Yin, Jun; Tetrahedron; vol. 73; 44; (2017); p. 6386 – 6391;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com