Synthetic Route of 6828-35-9,Some common heterocyclic compound, 6828-35-9, name is 5-Chloro-2-iodoaniline, molecular formula is C6H5ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-iodoaniline (1.000 g, 4.57 mmol) in THF (15 mL) and i-Pr2NH (3.20 mL, 22.83 mmol) were added 1-bromo-2-ethynylbenzene 5g (1.16 g, 5.48 mmol), PdCl2(PPh3)2 (0.048 g, 0.068 mmol,1.5 mol%), and CuI (0.026 g, 0.136 mmol, 3 mol%). The mixture wasstirred at r.t. under N2 for 2 h. After completion of the reaction, the mixture was extracted with NH4Cl (0.5 M) and EtOAc (3 ×). The combined organic phases were dried (Na2SO4) and evaporated. The residue was purified by column chromatography (petroleum ether/EtOAc, 80:20) to give 6g as a brown oil; yield: 1.205 g (87%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-2-iodoaniline, its application will become more common.
Reference:
Article; Rode, Navnath D.; Arcadi, Antonio; Chiarini, Marco; Marinelli, Fabio; Synthesis; vol. 49; 11; (2017); p. 2501 – 2512;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com