26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 26059-40-5
2-(2-iodophenyl)ethanol 91 (4.85 g, 19.60 mmol) was dissolved in acetonitrile (60 mL) and IBX (16.0 g, 57.10 mmol) was added at room temperature. The mixture was stirred under reflux for 1 hour and then cooled to room temperature. The mixture was then filtered through a large cotton plug, and the filtrate was concentrated and purified through a silica plug. The crude aldehyde was obtained as oil and used without further purification. A THF (10 mL) solution of the aldehyde obtained above was added to a solution of 2-methyl-1-propenylmagnesium bromide (64 mL, 32 mmol, 0.5 M in THF) in THF (65 mL) at 0 C via cannula, over 40 minutes. The reaction was allowed to warm to room temperature and stirred overnight. The reaction was then diluted with hexanes, quenched with saturated NH4Cl and extracted with diethyl ether (3 x 50 mL). The combined extracts were dried over MgSO4 and purified via silica gel flash chromatography (EtOAc/hexanes) to give iodide 11 as oil (3.37 g, 57%, 2 steps).
The synthetic route of 26059-40-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fischer, Derek; Nguyen, Thong X.; Trzoss, Lynnie; Dakanali, Marianna; Theodorakis, Emmanuel A.; Tetrahedron Letters; vol. 52; 38; (2011); p. 4920 – 4923;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com