Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H9IO2
General procedure: HOBT (1.2 equiv.) was added to an ice-cooled solution of EDCI (1.2 equiv.) in anhydrous DMF (10 mL) under N2. The resulting solution was allowed to stir for 10 min. at 0 C, followed by the addition of the appropriate acid 7a-7l (1.2 equiv.) and DIPEA (2.5 equiv.). The resulting solution was stirred for another 15 min at 0 C, after which a solution of amine 6 (1.0 equiv.) in anhydrous DMF (5 mL) was added. The resulting reaction mixture was allowed to stir first at 0 C for 30 mins, then at rt for 5 h. The reaction mixture was then evaporated to dryness under vacuum. Saturated NaHCO3 solution (10 mL) was then added to the resulting crude followed by extraction of the aqueous layer using dichloromethane (3 x 15 mL). The combined organic layer was dried over Na2SO4 and evaporated to dryness under vacuum to afford the corresponding amides which were purified using flash column chromatography (30 – 50 % ethyl acetate -petroleum ether).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kapadia, Nirav; Ahmed, Shahrear; Harding, Wayne W.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 14; (2016); p. 3216 – 3219;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com