Related Products of 450412-28-9,Some common heterocyclic compound, 450412-28-9, name is 1-Bromo-3-chloro-2-iodobenzene, molecular formula is C6H3BrClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A round bottom flask was charged with 13.45 g of phenylboronic acid, 110.29 mmol) was added dropwise a solution of 1-bromo-3-chloro-2-iodobenzene (35 g, 110.29 mmol), Pd (PPh3) 4 (1.27 g, 1.10 mmol), NaOH (4.41 g, 110.29 mmol), THF (485 mL) and water (243 mL). Then, the mixture is heated under reflux at 80 C . When the reaction is complete, dilute with distilled water at room temperature and extract with methylene chloride and water. The organic layer was dried over MgSO4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 18.59 g of the product. (Yield: 63%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-chloro-2-iodobenzene, its application will become more common.
Reference:
Patent; DUK SAN NEOLUX CO., LTD.; KIM, Hyo Jin; PARK, Nam Jin; KIM, Seul Gi; HWANG, Sun Pil; (46 pag.)KR2017/95602; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com