Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H4F3I
General procedure: To a resealable Schlenk tube were added indole (1.0 mmol), K3PO4 (0.424 g, 2.0 mmol), and MCM-41-2N-CuI (88 mg, 0.04 mmol), and the reaction vessel was fitted with a rubber septum. The vessel was evacuated and back-filled with argon and this evacuation/back-fill procedure was repeated one additional time. The aryl halide (1.2 mmol) and toluene (2 mL) were then added under a stream of argon. The reaction tube was quickly sealed and the contents were stirred while heating in an oil bath at 110 C for 24-48 h. After completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ethyl acetate (5 mL), and filtered. The MCM-41-2N-CuI complex was washed with distilled water (2×5 mL), ethanol (2×5 mL), and Et2O (2×5 mL) and reused in the next run. The filtrate was concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel (petroleum/ethyl acetate=50:1 to 4:1) to provide the desired product.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 401-81-0.
Reference:
Article; Xiao, Ruian; Zhao, Hong; Cai, Mingzhong; Tetrahedron; vol. 69; 26; (2013); p. 5444 – 5450;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com