Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, SDS of cas: 112671-42-8
Under the protection of argon, dibenzothiophene-4-boronic acid (29.2 g, 128.1 mmol), 4-bromo-1-iodo-2-nitrobenzene (35.0 g, 106.8 mmol), Na2CO3 were sequentially added to the reaction flask. (34.0 g, 320.4 mmol), tetrakistriphenylphosphine palladium (6.17 g, 5.3 mmol), toluene (640 ml) and ethanol (160 ml), and the reaction mixture was stirred at 90 C for 3 hours. After the stirring was completed, poured into distilled water (160 ml), cooled to room temperature, and the organic phase was extracted with ethyl acetate.The organic phase is concentrated and combined by column chromatographyC5 (33.6 g, 82%).
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Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhou Wenting; Cai Hui; (39 pag.)CN108822020; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com