Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 202865-85-8
Compound K45 can be synthesized by a person of ordinary skill following Scheme 25 illustrated in FIG. 26. In the first step, compound S25-1 (available for purchase from ArkPharm, Inc., CAS No. 57103-02-3) is combined with BOC anhydride and DMAP in THF. The mixture is taken, without purification and combined with HNPh2, tBu3P, and Pd2dba3 in toluene. This mixture is taken, without purification and combined with TFA to produce compound S25-2. In the second step, compound S25-2 is combined with compound S25-3 (available for purchase from Alfa Aesar, CAS No. 202865-85-8), K3P04 and Cul in toluene at 80 C and stirred for 6 hours to form compound S25-4. In the third step, compound S25-4 is cooled to -78 C in hexanes solution before dropwise addition of nBuLi and subsequent dropwise addition of Bu3SnCl to form compound S25-5. In the fourth step, compound 25-5 is combined with compound S25-6 (available for purchase from Acros Organics, CAS No. 106-37-6) and Pd(OAc)2 in THF at 45 C and stirred for 24 hours to give compound S25-6. In the fifth step, compound S25-6 is cooled to -78 C in hexanes solution before dropwise addition of nBuLi and subsequent dropwise addition of Bu3SnCl to form compound S25-7. In the sixth step, compound S25-7 is combined with compouns S25-8 (available for purchase from eNovation Chemicals, CAS No. 40000-20-2) and Pd(OAc)2 in THF at 45 C and stirred for 24 hours to give compound K45. It is understood that steps 1, 2, 3, 4, 5, and 6 can be performed and optimized by a person having ordinary skill in the art without undue experimentation.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 202865-85-8.
Reference:
Patent; Harvard College Dean Deng; A ·asipulu-gujike; R ·gemaisi-bomubaleierli; T ·D·xiseer; J ·akuileila-aipalakuilei; R ·P·yadangsi; D ·maikelaolin; D ·K·duweinade; (333 pag.)CN106661001; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com