In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25309-64-2 as follows. category: iodides-buliding-blocks
General procedure: to a stirred solution of iodo benzene (1.0 mmol) and trans-4-hydroxy-L-proline (2.0 equiv) in dry DMSO (3.0 mL) at rt was added CuI (20 mol %) followed by Cs2CO3 (2.5 equiv) and heated at 110 C for 24 h. The progress of the reaction was monitored by TLC. After the reaction was complete, the reaction mixture was allowed to cool, and a 1:1 mixture of ethyl acetate/water (20 mL) was added. The combined organic extracts were dried with anhydrous Na2SO4. The solvent and volatiles were completely removed under vacuum to give the crude product, which was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 9:1) to afford the corresponding coupling product.
According to the analysis of related databases, 25309-64-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Reddy, V. Prakash; Kumar, A. Vijay; Rao, K. Rama; Tetrahedron Letters; vol. 52; 7; (2011); p. 777 – 780;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com