Related Products of 116632-39-4, These common heterocyclic compound, 116632-39-4, name is 5-Bromo-2-iodotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) 4-Bromo-4′-fluoro-2-methylbiphenyl 4-Bromo-1-iodo-2-methylbenzene (10.5 g, 35.4 mmol) was dissolved in 1,2-dimethoxyethane (100 mL), and (4-fluorophenyl)boronic acid (7.4 g, 52.9 mmol), [1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride-dichloromethane adduct (1.5 g, 1.84 mmol) and potassium phosphate hydrate (18.8 g, 88.6 mmol) were added, followed by stirring at room temperature for 16 hours under a nitrogen atmosphere. After the insoluble materials in the reaction solution were filtered off, the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (Moritex Corporation, elution solvent:hexane), and a fraction corresponding to the Rf value=0.60 (hexane) by thin layer chromatography was concentrated under reduced pressure to afford the title compound (5.1 g, 19.2 mmol) as a colorless oil (yield 54%). 1H-NMR (500 MHz, CDCl3) delta: 7.42 (1H, s), 7.36 (1H, d, J=8 Hz), 7.27-7.21 (2H, m), 7.13-7.04 (3H, m), 2.22 (3H, s).
The synthetic route of 116632-39-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2011/112103; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com