Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1829-28-3, name is Ethyl 2-iodobenzoate, A new synthetic method of this compound is introduced below., Safety of Ethyl 2-iodobenzoate
0.54 g (5 mmol) of 2.76 g (10 mmol) of o-phenylenediamine and ethyl iodobenzoate were weighed into a microwave reaction tube, and cuprous iodide (80 mg, 0.5 mmol), potassium phosphate (3.18 g, 15 mmol), Then, an appropriate amount of ethylene glycol and magnetron were added to the microwave reaction tube, and the microwave reaction was carried out under the protection of nitrogen at 180 C. After 1 h, the reaction was stopped, and the TLC detection was completed. Ethyl acetate (3 × 100 mL) and an appropriate amount of water and saturated NaCl solution were extracted, the organic layer was combined, an appropriate amount of anhydrous Na 2 SO 4 was added to remove water, suction filtration, and the filtered liquid was concentrated, and 1 g of silica gel was added for mixing.Separated using silica gel column chromatography,The eluent was (dichloromethane/methanol = 100/1) to give a bright yellow solid, 3, 0.68 g, yield 65%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Xinxiang Medical University; Xinxiang Medical School San Quan College; Yan Fulin; Wang Yawen; Yan Jianwei; Yin Tiantian; Ma Jinshuo; (15 pag.)CN110183387; (2019); A;,
Iodide – Wikipedia,
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