In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 640280-28-0 as follows. Computed Properties of C7H3BrF3I
Intermediate C: 5-(2-Bromo-5-(trifluoromethyl)phenyl)-l-methyl-lH-pyrazole A 75-mL pressure vessel was charged with l-bromo-2-iodo-4- (trifluoromethyl)benzene (2.015 g, 5.74 mmol), l-methyl-5-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)-lH-pyrazole (Aldrich, St. Louis, MO, 1.374 g, 6.60 mmol), potassium phosphate (2.438 g, 11.48 mmol), and PdCi2(dppf)-CH2Ci2 adduct (Strem Chemicals Inc., Newburyport, MA, 0.469 g, 0.574 mmol). The vessel was flushed with Ar (g), then DMF (19.14 ml) was added. The vial was sealed and placed in an 80 C oil bath for 2 hours. The mixture was diluted with water and extracted with EtOAc (3x). The combined organic extracts were washed with brine, dried over sodium sulfate, filtered, and concentrated. The residue was chromatographed on an 80 g silica gel column to give 5-(2-bromo-5-(trifluoromethyl)phenyl)-l-methyl-lH-pyrazole +H]+ = 307.0.
According to the analysis of related databases, 640280-28-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Iodide – Wikipedia,
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