Related Products of 108078-14-4, These common heterocyclic compound, 108078-14-4, name is 2-Iodo-3-methylbenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 289; 292 2912-iodo-3-methylbenzoic acid ethyl ester (289)A solution of the 2-iodo-3-methylbenzoic acid (6g-0.023mol) in EtOH (15OmL) is treated with concentrated HCl (2OmL) and refluxed for 48h. After removal of the EtOH in vacuo, the residue is diluted with water (125mL) and cooled to 00C in an ice bath. The pH is adjusted to 10 with solid NaOH pellets and extracted with EtOAc (3 x 75mL). The organic extracts are washed with water (2 x 5OmL) and brine (2 x 5OmL) and dried over MgSO4. Concentrated in vacuo to give the product as a pale yellow oil. (6g, 90%).LC/MS(ES+) m/z 291
Statistics shows that 2-Iodo-3-methylbenzoic acid is playing an increasingly important role. we look forward to future research findings about 108078-14-4.
Reference:
Patent; SANOFI-AVENTIS; WO2008/151211; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com