Application of 2265-91-0,Some common heterocyclic compound, 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, molecular formula is C6H3F2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound SM (2g, 8.3mmol),CuI (100 mg, 0.5 mmol) and Pd(PPh3) 2Cl2 (350 mg, 0.5 mmol)Add to the three-necked flask, after replacing N2 three times,DMF (20 ml) and trimethylethynyl silicon (1.31 g, 13.3 mmol) were added.Replace with N2 and finally add triethylamine (1.35 g, 13.3 mmol).After the N2 substitution, the mixture was stirred at 70 C for 3 hours. After complete reaction,The system was cooled to room temperature, filtered through celite, and the filtrate was diluted with water.Extract with ethyl acetate, combine the organic phases, and wash with water.Wash once with saturated brine, dry over anhydrous sodium sulfate, filtered, and then evaporated.The oil was purified by column chromatography to give ((3,5-difluorophenyl)ethynyl)trimethylsilane (1.56 g, yield: 90%, brown oil).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Difluoro-5-iodobenzene, its application will become more common.
Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Luo Xiaoyong; Dong Zhenwen; Li Xiaoyong; Yu Hua; Zeng Hong; Song Hongmei; Wang Ying; Wang Lichun; Wang Jingyi; (49 pag.)CN109293652; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com