Application of 202865-85-8,Some common heterocyclic compound, 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen atmosphere, 1-bromo-4-iodo-2-methylbenzene (1.0 g), (4-methoxyphenyl)methanethiol (520 mg) To a 1,4-dioxane solution (20 mL) containing tris (dibenzylideneacetone)dipalladium (80 mg) and 4,5-bis (diphenylphosphino) -9,9- dimethylxanthene (100 mg) wasadded diisopropylethylamine 1.2 mL) was added, and the mixture was reacted under reflux for90 minutes. The reaction mixture was cooled, water was added, and the mixture was extractedtwice with ethyl acetate (30 mL). The organic layer was washed with saturated brine, dried overanhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtainedresidue was purified by column chromatography (heptane: ethyl acetate = 20: 1) to obtain (4 -bromo-3-methylphenyl) (4-methoxybenzyl) sulfane (907 mg, yield 83%) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-iodo-2-methylbenzene, its application will become more common.
Reference:
Patent; Ishihara Sangyo Co., Ltd.; Ueki, Toshihiko; Yamada, Ryu; Izakura, Kenji; (30 pag.)JP2017/75131; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com