Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, A new synthetic method of this compound is introduced below., Product Details of 31827-94-8
A 1 L round bottom flask equipped with a mechanical stirrer, thermocouple, and a reflux condenser was charged with 2′-bromo-4-iodoacetophenone (44.0 g, 0.135 mol), potassium acetate (19.9 g, 0.203 mol), benzyl triethylammonium chloride (1.5 g, 0.007 mol) and 1,2-dichloroethane (425 mL). The reaction mixture stirred at 70 C. for 4 hours then was cooled to 25 C. Water (250 mL) was added and the contents were shaken in a separatory funnel. The dichloroethane layer was separated and was washed with aq. saturated sodium bicarbonate (200 mL) and brine (100 mL). The dichloroethane was dried over sodium sulfate, filtered, and the solvents were removed under reduced pressure to give product as a tan solid (41.2 g, 97% yield): mp 103-107 C.
The synthetic route of 31827-94-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tisdell, Francis Eugene; Bis, Scott Jerome; Hedge, Vidyadhar Babu; Martin, Timothy Patrick; Perreault, Denise Marie; Yap, Maurice Chee Hoong; Guenthenspberger, Katherine Anne; Dripps, James Edwin; Gifford, James Michael; Schoonover, Joe Raymond; Karr, Laura Lee; Dintenfass, Leonard Paul; Neese, Paul Allen; US2004/6108; (2004); A1;,
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