Adding a certain compound to certain chemical reactions, such as: 766-99-4, name is 1-Ethynyl-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766-99-4, Product Details of 766-99-4
4-iodophenylacetylene 114 mg (0.5 mmol), silver nitrite 115.5 mg (0.75 mmol), N-chlorosuccinimide133.5 mg (1.0 mmol) was sequentially added to a 10 mL pressure-resistant sealed container, and 5 mL of acetonitrile was further added.The mixture was stirred at room temperature, and the reaction was checked by TLC, and the reaction was completed in 6 hours.The reaction solution was diluted with 10 mL of dichloromethane, and filtered to give a clear liquid.Separation by column chromatography (extraction of petroleum ether/ethyl acetate in a volume ratio of 50:1)The eluate containing the desired product were collected and the solvent was evaporated to give 4-iodo-benzonitrile as a white solid 52.7mg (46% yield).
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Reference:
Patent; Zhejiang University of Technology; Liu Yunkui; Zhang Jian; Bao Hanyang; (9 pag.)CN107641088; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com