Application of 624-76-0, A common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, molecular formula is C2H5IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.5 equivalents of 2-iodoethanol was added to 2,3,3-trimethylindolenine and refluxed for 18 hours in toluene solvent to obtain intermediate 1. One equivalent of N, N’-diphenylformamidine and one equivalent of triethyl orthoformate was added to Intermediate 1 obtained, and refluxed in an ethanol solvent for 16 hours to obtain Intermediate 2.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Samsung SDI Co., Ltd; Lee Yeong; Kim Gyu-yeong; Choi Eun-jeong; Shin Myeong-yeop; Han Gyu-seok; (43 pag.)KR2018/76149; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com