Some common heterocyclic compound, 13421-13-1, name is 4-Chloro-2-iodobenzoic acid, molecular formula is C7H4ClIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 13421-13-1
In a MW tube was added 4-chloro-2-iodobenzoic acid (260 mg, 0.92 mmol), 1 H-1 , 2,3- Triazole (0.1 1 ml_, 1 .84 mmol) and (1 R,2R)-N 1 ,N2-dimethylcyclohexane-1 ,2-diamine (0.03 ml_, 0.18 mmol). To these solids were added 1 ,4-Dioxane (1 ml_) and Water (0.1 ml_), then Cul (8.77 mg, 0.05 mmol) and finally Cs2C03 (0.6 g, 1 .84 mmol). The mixture was then warmed to 100 C for 2.5 hrs and left at RT O/N . HCI 6 N was added until pH 2, then volatiles were removed under vacuum and the crude material was purified by RP on C18 column (from H20/CH3CN 95:5 + 0.1 % of FA to H20/CH3CN 5:95 + 0.1 % of FA) affording 4-chloro-2-(2H-1 ,2,3-triazol-2-yl)benzoic acid (p182, 120 mg, y= 58%) as white solid. MS (mlz): 223.9 [MH]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13421-13-1, its application will become more common.
Reference:
Patent; CHRONOS THERAPEUTICS LIMITED; MICHELI, Fabrizio; BERTANI, Barbara; GIBSON, Karl Richard; DI FABIO, Romano; RAVEGLIA, Luca; ZANALETTI, Riccardo; CREMONESI, Susanna; POZZAN, Alfonso; SEMERARO, Teresa; TARSI, Luca; LUKER, Timothy Jon; (275 pag.)WO2019/43407; (2019); A1;,
Iodide – Wikipedia,
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