Adding a certain compound to certain chemical reactions, such as: 59528-27-7, name is (4-Iodophenyl)methanamine hydrochloride, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59528-27-7, name: (4-Iodophenyl)methanamine hydrochloride
4-Iodobenzylamine hydrochloride (29.1 mg, 0.1 mmol) and Me4NF·4H2O (75.9 mg, 0.46 mmol) were dissolved in DMF-MeOH (9:1, v/v, 3 mL) and the solution was degassed. Then, (PPh3)2PdCl2 (12.9 mg, 18.4 mumol) and dry peptide-bound resin (200 mg, 0.46 mmol/g loading) were added and the yellow suspension was stirred for 20 h. Identical workup as for 2 gave the target compound as a white solid; yield: 5.3 mg (26%).
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Reference:
Article; Strack, Martin; Metzler-Nolte, Nils; Albada, H. Bauke; Synthesis; vol. 46; 17; (2014); p. 2293 – 2296;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com