Application of 3930-83-4, A common heterocyclic compound, 3930-83-4, name is 2-Iodobenzamide, molecular formula is C7H6INO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-iodobenzamide (3a) (2.0 mmol) in DMSO(3 mL), was added NaN3 (260 mg, 4.0 mmol) and CuBr (29 mg,0.2 mmol). The reaction mixture was stirred at 50 C under air for4 h. Water (30 mL) was added to the mixture, and then extractedwith ethyl acetate (15 mL) for three times. The extraction waswashed with saturated NaCl solution, dried over anhydrous Na2SO4and concentrated under reduced pressure. The residuewas purifiedby column chromatography on silica gel using petroleum ether/ethyl acetate (8:1) as the eluent to give 8 as a light brown solid(269 mg, 83% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Li, Ting; Chen, Minglu; Yang, Lei; Xiong, Zhengxin; Wang, Yongwei; Li, Fei; Chen, Dongyin; Tetrahedron; vol. 72; 6; (2016); p. 868 – 874;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com