Synthetic Route of 2142-70-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2142-70-3, name is 1-(2-Iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows.
101671 A solution of(R)-CBS (20.32 mL, 20.32 mmol) and commercial 7-1 (5 g, 20.32 mmol) in THF (102 mL) was treated with BH3.THF (20.32 mL, 20.32 mmol, 1M in THF), diluted with an additional 50 mL of THF, delivered via syringe pump at 75 mL / hr. Quenched with 2N HC1 (50 mL), extracted into EtOAc (150 mL), and dried over Sodium sulfate before concentrating in vacuo. Material was taken up in dichloromethane and filtered. Filtrate was purified by normal phase chromatography (0-30% EtOAc in hexane). Isolated material chirally separated (ChiralPak AD-H) to yield 7-2 as a white solid.
The chemical industry reduces the impact on the environment during synthesis 1-(2-Iodophenyl)ethanone. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PERO, Joseph, E.; LEHMAN, Hannah, D. G. F.; KELLY, Michael, J., III; ZHAO, Lianyun; ROSSI, Michael, A.; LI, Dansu; GILBERT, Kevin, F.; WOLKENBERG, Scott; MULHEARN, James; LAYTON, Mark, E.; DE LEON, Pablo; WO2014/66490; (2014); A1;,
Iodide – Wikipedia,
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