77317-55-6, name is Methyl 2-amino-5-iodobenzoate, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Methyl 2-amino-5-iodobenzoate
Methyl anthranilate (15) (2.0 g, 13.2 mmol), granulatediodine (3.36 g, 13.2 mmol) and hydrogen peroxide-urea(1.24 g, 13.2 mmol), were dissolved in 20 mL of ethylacetate. The reaction mixture was stirred for 1.5 h at roomtemperature and then washed with sodium thiosulfate(3 × 10 mL) and water (3 × 10 mL); then solvent wasevaporated under reduced pressure to afford methyl2-amino-5-iodobenzoate (16) as a brown solid (3.33 g,yield 91%). The solid was hydrolyzed using NaOH/MeOH(5%) to give 2-amino-5-iodobenzoic acid (17) (2.81 g, yield89%). Finally, the acid was cyclized with triphosgene andtriethylamine as base affording 6-iodoisatoic anhydride(6-iodo-1H-benzo[d][1,3]oxazine-2,4-dione, 2) with a76% yield (2.34 g).
The synthetic route of 77317-55-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; De La Cruz, Armando; Vega-Acevedo, Carlos Alejandro; Rivero, Ignacio A.; Chavez, Daniel; Journal of the Brazilian Chemical Society; vol. 29; 8; (2018); p. 1607 – 1611;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com