Synthetic Route of 14452-30-3,Some common heterocyclic compound, 14452-30-3, name is 1-(3-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: 2-(3-iodophenyl)propan-2-ol; To a solution of 3-iodo-acetophenone (15g, 61 mmol) in 10OmL THF at -78 0C was slowly added MeMgBr (6OmL of a 1.4M solution in THF, 84 mmol) and the solution was stirred for 1 hour as it warmed to 0 0C. The reaction was quenched with saturated NH4Cl and the crude product was extracted with ether (2x) and the organic phases were dried over Na2SO4, filtered and concentrated in vacuo. The crude was purified by flash (5-10% EA/hex) to give the desired product.
The synthetic route of 14452-30-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2007/14454; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com