Related Products of 610-97-9,Some common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of methyl 2-iodobenzoate (5.0 g, 19.08 mmol, 1 equiv) and NBS (3.73 g, 20.99 mmol, 1 .1 equiv) in acetic acid (10 mL) was added H2S04 (10 mL) drop wise at 20-40C. The reaction mixture was stirred for 88 h at room temperature and then heated to 50C & stirred for 4 h. The reaction mixture was cooled to 10C and quenched with cold water (40 mL) and extracted with DCM (3 x 50 mL). The organic layer was washed with 5% sodium bicarbonate (2 x 50 mL), 10% Na2S03 solution (50 mL), and water (50 mL), and then dried over sodium sulphate, and evaporated to obtain methyl 5-bromo-2- iodobenzoate as crude product which was purified over silica gel flash column chromatography. The compound eluted out in 10 % ethyl acetate in hexanes. The pure fractions were evaporated to obtain methyl 5-bromo-2-iodobenzoate as off white solid (5 g, 77%). NMR (400 MHz, CDCI3) delta ppm 3.94 (s, 3 H).7.26 – 7.29 (m, 1 H), 7.83 (d, J=8.4 Hz, 1 H), 7.93 (d, J=8.8 Hz, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-iodobenzoate, its application will become more common.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey; KETHIRI, Raghava Reddy; KRISTAM, Rajendra; VENKATESHAPPA, Chandregowda; (162 pag.)WO2018/15879; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com