Related Products of 34883-46-0, A common heterocyclic compound, 34883-46-0, name is 1-Iodo-2-phenoxybenzene, molecular formula is C12H9IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 1.0 equivalent of intermediate Bn was dissolved in 120 ml of 0.4 M anhydrous tetrahydrofuran (THF).After cooling to -78 C, slowly add n-butyllithium (n-BuLi) (2.5 M,1.0 equivalent of the reaction solution was formed and stirred for 1 hour. then,The intermediate An (0.7 eq.) was added to the reaction solution and stirred at 25 C for an additional 3 hours.After the completion of the reaction, the reaction solution was cooled with a saturated aqueous solution of ammonium chloride, and then extracted with an organic solvent to separate the organic phase. After concentration, it was recrystallized from petroleum ether to obtain a white solid product. The white solid product was analyzed by FD-MS to determine the chemical structural formula, yield, and molecular formula and mass determined by FD-MS analysis of each of the intermediates C1 to C12 are listed in Table 3-1.
The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NICHEM FINE TECHNOLOGY CO., LTD.; LU, TAI-NI; WU, HUI-LING; SHIEH, SHWU-JU; CHEN, CHI-CHUNG; (84 pag.)TWI644912; (2018); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com