Application of 5460-32-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5460-32-2 as follows.
In a 100 ml reaction flask equipped with an exhaust gas absorption device 2.64 g of 4-iodo-1,2-dimethoxybenzene and 26 ml of acetic acid, then add 30ml concentrated hydrochloric acid, control the reaction liquid temperature 15-20 degrees,dilute 10 ml of hydrogen peroxide diluted with 5 ml of glacial acetic acid, drop finished, dept at 15-25 degrees for 12 hours for sample HPLC monitoring, raw materials less than 1percent about 30 ml of saturated sodium bisulfite solution was added and filtered, the filter cake was transferred to a 100 ml reaction flask, 10 ml of acetic acid and 30 ml of water were added, The temperature was raised to 50-55 ° C for 1 hour, down to room temperature filtration, with a little water rinse, TLC test for a single spot. To give 3.04 white solid in 82percent yield. HPLC greater than 97.9 percent
According to the analysis of related databases, 5460-32-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Tianjin Chengjian University; GU, Ying-chun; FEI, Xue-ning; Ling, Big Yong; Li, Ran; JIAO, Xiu-mei; (6 pag.)CN105732333; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com